FLASH ultra-high dose rates in radiotherapy: preclinical and radiobiological evidence

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A. Borghini, C. Vecoli, Luca Labate, D, Panetta, M.G. Andreassi, L.A. Gizzi

International Journal of Radiation Biology, 98:2, 127-135

 

Abstract

Flash radiotherapy (FLASH-RT) is currently being regarded as the next breakthrough in radiation treatment of cancer, delivering ultrahigh radiation doses in a very short time, and sparing normal tissues from detrimental injury. Here we review the current evidence on the preclinical findings as well as the radiobiological mechanisms underlying the FLASH effect. We also briefly examine the scenario of available technologies for delivering FLASH dose-rates for research and their implications for future clinical use.

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